The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death
نویسندگان
چکیده
منابع مشابه
Sam68 is cleaved by caspases under apoptotic cell death induced by ionizing radiation
The RNA-binding protein Sam68, a mitotic substrate of tyrosine kinases, has been reported to participate in the cell cycle, apoptosis, and signaling. In particular, overexpression of Sam68 protein is known to suppress cell growth and cell cycle progression in NIH3T3 cells. Although Sam68 is involved in many cellular activities, the function of Sam68, especially in response to apoptotic stimulat...
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Bloom syndrome helicase (BLM) has key roles in homologous recombination repair, telomere maintenance, and DNA replication. Germ-line mutations in the BLM gene causes Bloom syndrome, a rare disorder characterized by premature aging and predisposition to multiple cancers, including breast cancer. The clinicopathologic significance of BLM in sporadic breast cancers is unknown. We investigated BLM ...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2001
ISSN: 1537-744X
DOI: 10.1100/tsw.2001.157